<?xml version="1.0" encoding="US-ASCII"?>
<!-- Generated by CompSci Transform (tm) - http://www.compsciresources.com -->
<!-- Created: Wed Apr 16 12:02:08 UTC 2025 -->
<linkbase xmlns="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd" xmlns:xbrldt="http://xbrl.org/2005/xbrldt">
  <roleRef xlink:type="simple" xlink:href="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd#IndividualsOnly" roleURI="http://xbrl.sec.gov/ecd/role/IndividualsOnly"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-default" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-default"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#dimension-domain" arcroleURI="http://xbrl.org/int/dim/arcrole/dimension-domain"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#hypercube-dimension" arcroleURI="http://xbrl.org/int/dim/arcrole/hypercube-dimension"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#domain-member" arcroleURI="http://xbrl.org/int/dim/arcrole/domain-member"/>
  <arcroleRef xlink:type="simple" xlink:href="http://www.xbrl.org/2005/xbrldt-2005.xsd#all" arcroleURI="http://xbrl.org/int/dim/arcrole/all"/>
<!-- [WMV6][XcpuxYn59dz7vgYynUDuwG7r97K2jUTysl7vcz0lJt9uqgO9qQHmt9BQ98lPQIywI6RnikDrjyhmXCiSgYhymJesHGmP5PA0jE7AO59fvJXEmjKMopILy2X0wLqZp92Q0DDm7aJv7GzmISOUrgw1u/DjRXSAADVNvgZ8Rp6OkHCfbKCmSh+ViEFCbMQWAWoONY6jFWYVXbjCGVqoOpAA5Kbso1bUP864/XjZcl6tJ+ki2bwRhANAM1bQgSnVTdhhnpyJri/Hgq8Ck6x4kkgHayo8bBmBgDbo+o/+w2Rq4NivagBWeFIdqXYWQ86PiR4kyTXnY9Gc2Tuj1ixaPmGXoVClgzTuJ6Bn] CSR-->
  <definitionLink xlink:role="http://xbrl.sec.gov/ecd/role/IndividualsOnly" xlink:type="extended">
    <loc xlink:type="locator" xlink:label="ecd_AllIndividualsMember" xlink:href="https://xbrl.sec.gov/ecd/2024/ecd-2024.xsd#ecd_AllIndividualsMember"/>
    <loc xlink:type="locator" xlink:label="rani_TalatImranMember" xlink:href="rani-20250528.xsd#rani_TalatImranMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="rani_TalatImranMember" order="2" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="rani_MirHashimMember" xlink:href="rani-20250528.xsd#rani_MirHashimMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="rani_MirHashimMember" order="4" xbrldt:closed="true"/>
    <loc xlink:type="locator" xlink:label="rani_SvaiSanfordMember" xlink:href="rani-20250528.xsd#rani_SvaiSanfordMember"/>
    <definitionArc xlink:type="arc" xlink:arcrole="http://xbrl.org/int/dim/arcrole/domain-member" xlink:from="ecd_AllIndividualsMember" xlink:to="rani_SvaiSanfordMember" order="6" xbrldt:closed="true"/>
  </definitionLink>
</linkbase>
